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Drug interactions are most clinically important with insulin and sulfonylureas (hypoglycaemia risk), DPP-4 inhibitors (dont combine), and (for Mounjaro only) oral contraceptives and oral HRT

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These associations remained consistent across subgroup analyses, including patients using tirzepatide as adjunctive therapy to other first-line diabetes agents, among patients older than 60 and comparisons against individual GLP-1 drugs, including semaglutide and dulaglutide

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heart failure events alone showed an HR of 0.73 (95% CI, 0.580.92