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The recent data provide evidence that GLP-1R activation affects the mechanisms of signal transduction associated with insulin resistance, energy homeostasis of the brain, neurogenesis, synaptic functioning, neuroinflammation and other cell responses to stress, pathological protein aggregates, proteostasis, the cerebrovascular system, and the BBB [42]

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Evidence suggests HMB supplementation attenuates lean mass loss during caloric restriction or immobilization (Nissen & Sharp, 2003)

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