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GLP-1 drugs may have a role in specific, complex cases, but they carry real risks that deserve honest, thorough discussion before any decision is made (for informed consent)

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With more structural and dynamics studies on class B GPCRs, the activation process from inactive to active states via an intermediate state, i.e., allosteric communication between extracellular peptide binding and intracellular G protein coupling, will be better understood

doi: 10.1016/j.neuropharm.2014.10.007 73 Aviles-OlmosIDicksonJKefalopoulouZDjamshidianAEllPSoderlundTet al