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Clinical trial evidence on tirzepatide and thyroid safety The most important evidence for anyone evaluating tirzepatide with thyroid nodules comes from large-scale clinical trials

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So thats whats happening is that some physicians are prescribing them for people off-label

Eleven large CVOTs have investigated the impact of GLP-1RAs on major adverse cardiovascular events (MACE) defined as a composite of CV death, nonfatal MI, and nonfatal stroke or on maximum walking distance in peripheral artery disease (57, 58)

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