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Figure 4: Opportunities Outside of Diabetes and Obesity for Incretin Mimetics As mentioned earlier, NASH is an area that has attracted a high level of manufacturer attention, as the liver disease is associated with metabolic syndrome and represents an area of large commercial opportunity with significant unmet medical need

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Anyone taking a GLP-1 drug should notify their dentist so they can get extra care for their teeth as needed

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Elevated cortisol promotes fat storage, increases insulin resistance, and stimulates appetite through pathways that partially bypass GLP-1 signaling

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Over-the-counter remedies such as simethicone (for gas relief) or antacids may provide symptomatic relief

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Erratum in: Lancet Diabetes Endocrinol

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