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In an obesity rat model, LGP-MNs not only proved safer than conventional injection methods but also exhibited sustained and superior therapeutic outcomes in muscle layer delivery, including a 16.23% weight loss (3.06 times greater than conventional injections) (Figure 4b,c), a 55.20% reduction in gastric emptying rate, improved hepatic fat degeneration, and reduced blood lipid levels (Figure 4d,e)
CRF also mediates the anorexic effect of GLP-1 in chicks and mediates the inhibition of gastric emptying induced by GLP-1 in rats [228]
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Tambin se encuentran en desarrollo agonistas triples (GIP-GLP-1- glucagn) como retatrutida , que prometen mayor eficacia en prdida de peso
