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Managing GLP-1 Side Effects: Our Top Tips for Success GLP-1 agonists, like semaglutide and tirzepatide, are groundbreaking treatments for managing type 2 diabetes and obesity

We think thats a signal worth investigating. Ungar has studied online health discussions for years, including early efforts in 2011 to extract information about drug side effects from user-generated content

That said, this is a brand new federal program launching nationwide, and we expect some friction during the early months

In humans, Kelly et al

Canadian adult obesity clinical practice guidelines: pharmacotherapy for obesity management

Specifically, NICE suggests considering a DPP-4 inhibitor as a second agent when: The patient has a high risk of hypoglycaemia (making sulfonylureas less suitable) Weight management is a concern and a sulfonylurea's weight-gaining effects are undesirable An SGLT-2 inhibitor is contraindicated or not tolerated NICE NG28 recommends that in patients with established atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease, an SGLT-2 inhibitor should generally be prioritised often alongside or instead of metformin due to its organ-protective benefits