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Final Thoughts As science continues to evolve, medications once intended for metabolic health may show promise in broader clinical areasincluding cancer

Am J Clin Nutr 2013;97:1522

found that tirzepatide led to significant dose-dependent reductions in HbA1c levels when compared to a placebo, once-weekly GLP-1RAs, and basal insulin regimens

Weight loss effects may be smaller in people with type 2 diabetes, based on patterns observed with other agents in this class
Mechanically, insulin mainly activates two signal pathways: insulin receptor (IR)-insulin receptor substrates (IRS)-phosphatidylinositol 3-kinase (PI3K)-protein kinase B (AKT) signal pathway (Pollak, 2008)

Gradual increases over several weeks are recommended
