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The involvement of GLP-1R in the pathogenesis of CM may also be realized by regulating the activity of this pathway

They influence reward pathways, stress response, and circadian rhythm regulation

Muscle and lean mass Some of the weight lost on any GLP-1 medication is muscle, not fat

The SELECT trial recruited 17,604 patients with pre-existing CVD and BMI 27 kg/m 2 , but without a history of diabetes

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Over 32 weeks, CagriSema produced HbA1c reductions of 2.2 percentage points compared to 1.8 with semaglutide alone and 0.9 with cagrilintide alone, with CagriSema statistically superior to cagrilintide