glp 1 drugs muscle loss GLP-1 & What They Do Comment “Curious” for the deep

The SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes [1] [2]

JACC Heart failure (2023) 11(8 Pt 1):100010

Because the pill mimics natural hormone functions, it travels to the brain to target the reward centers that drive overeating, says Sara Velayati, MD, an obesity medicine specialist at the Fleischer Institute Medical Weight Center at Montefiore Einstein in New York

The creatures glucose-regulating system must therefore possess remarkable flexibility and, crucially, the hormonal signals that trigger insulin release must be extraordinarily durable

2012 Jan;38(1):104-10

Lower doses may not achieve the same blood sugar or weight loss outcomes as full therapeutic levels