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Two studies were published in the impactful New England Journal of Medicine [Reference Weghuber, Barrett and Barrientos-Prez1,Reference Arslanian, Hannon and Zeitler2], research motivated, as noted by the authors, in no small measure precisely because the currently approved medications for pediatric obesity and type 2 diabetes have proven to be limited in their effectiveness and fraught with adverse events [Reference Woodard, Louque and Hsia3]

Some women report increased hunger and cravings

Type 2 Diabetes: A chronic condition characterized by insulin resistance, where the bodys cells do not respond effectively to insulin, and/or decreased insulin production over time

Some individuals may feel discouraged if results are not immediate

GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet

In a recent observational study, individuals who discontinued semaglutide or tirzepatide within the first three months lost only 3.6% of their body weight, while those who quit between three and twelve months lost 6.8%