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Clinicians should consider prioritising review for people with type 2 diabetes on the affected GLP-1 RA preparation where: HbA1c greater than 86mmol/mol in the previous 3 to 6 months HbA1c greater than 86mmol/mol prior to starting the GLP1-RA HbA1c not recorded in the previous 6 months Urine albumin creatinine ratio (uACR) greater than 30mg/mmol Self-monitoring glucose readings (or Continuous Glucose Monitoring, where available) are persistently above individualised target range

Pharmaceutical and peptide interventions that mimic this effect offer similar potential benefits without requiring hours of cardio

Through the TrimRx platform, patients may be prescribed Compounded Semaglutide or Compounded Tirzepatide

This change can prevent enough blood from reaching the brain, which causes the body to react with warning signs

Understanding your genetic predispositions in GLP-1 and metabolic pathways may provide context for which administration route aligns best with your physiology
