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Most participants tolerate this step with minimal new symptoms
The supported moves are smaller meals, fiber, hydration, and clinician-guided dose adjustments (Wharton and colleagues, review, 2021)
Within this framework, glucagon-like peptide-1 (GLP-1) receptor agonists (RAs), originally developed for the treatment of type 2 diabetes (T2D), have recently shown cardioprotective effects beyond their role in glycaemic control
Shares of the Danish drugmaker fell 16% on the news that Novos CagriSema delivered 20.2% weight loss in 84 weeks, compared with 23.6% for Lillys tirzepatide, aka Zepbound
Similar findings are reported for the combination of insulin with DPP-4 inhibitors [909]
The major findings from these studies are summarized below
