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Increasing evidence has identified that diabetes mellitus (DM) increases the risk of HFpEF

Objective We aimed to investigate the efficacy of a moderate-to-vigorous intensity exercise program and glucagon-like peptide-1 receptor agonist treatment alone or in combination during weight maintenance for physical fitness

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risks: Early phase 2 data show even the lowest semaglutide dose (0.05 mg/day) drives meaningful weight loss (67% at one year) with fewer GI side effects, and tirzepatide 1 mg/week yields modest A1c and weight reductions with better tolerability