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Matveyenko AV et al

Part of our reward system, dopamine has multiple powerful facets: Drives action towards rewards around survival (food, water, sex, promotion, etc.) It's the "do that again" player but It also drives noveltyloses effect with repeated source or behavior It's spiked by drugs of addiction creating a narrowing of focus and pleasure All habitual and addictive behavior requires dopamine to spike in a particular area of the brain called the nucleus accumbens

16 To ensure that the severity of DR did not confound the study results for the preexisting DR subgroup, we did a look-back on individuals with vs without GLP-1 RA prescriptions to assess the number of individuals with varying severity of DR at baseline

But while the standard dosing protocols are effective for many, they dont work for everyone

Long-term effectiveness, sustainability of weight loss, and disease-modifying capacity in nonmetabolic disease must also be prioritized in future research