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Towards tailored obesity treatment choices based on obesity-related complications Ectopic fat deposition in different organs results over time in progressive metabolic dysfunction and the development of organ-specific metabolic complications including T2D, MASLD/MASH and HFpEF [108]

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A., A Prospective, ClaimsBased Assessment of the Risk of Pancreatitis and Pancreatic Cancer With Liraglutide Compared to Other Antidiabetic Drugs, Diabetes, Obesity & Metabolism 16 (2014): 273275

Constipation may be alleviated through increased dietary-fiber and fluid intake, and regular physical activity

GLP-1 agonists can cause significant gastrointestinal side effects like nausea, vomiting, and diarrhea, along with risks of pancreatitis, gallbladder issues, and gastroparesis

In addition, other patient-specific treatment strategies tailoring the use of GLP-1 RAs and other options to the HF phenotype and stage are likely also valuable to study and validate