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GIP showed a diminished effect in boosting insulin secretion in T2D patients, for reasons that are still not understood

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Semaglutide is a GLP-1 receptor agonist , meaning it mimics a naturally occurring hormone called glucagon-like peptide-1
25 DPP4 inhibitors are classified according to chemical nature into two classes: the peptidomimetics and the non-peptidomimetics

This specific localization within the GCL is of profound clinical relevance, as retinal ganglion cells are the primary neurons that degenerate in glaucoma and are also critically affected during the early neurodegenerative stages of diabetic retinopathy [38, 39]

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