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T2DM , .GLP-1/GIP/GCG SignalingFigure 1

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The Bottom Line GLP1 therapies are changing the game for T2D, and their influence is continuing to spread across the broader chronic disease landscape

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Despite their established glucose-lowering effects, there is no consensus among global experts and modern guidelines regarding the priority of SUs in relation to other therapeutic options, given the lack of evidence that SUs are associated with a low risk of macrovascular events and excess mortality