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Is regular exercise an effective strategy for weight loss maintenance

For patients in whom GLP-1 receptor agonists are not suitable, NICE NG28 recommends several alternative classes of glucose-lowering therapy

Newsome P, Francque S, Harrison S, Ratziu V, Van Gaal L, Calanna S, Hansen M, Linder M, Sanyal A (2019) Effect of semaglutide on liver enzymes and markers of inflammation in subjects with type 2 diabetes and/or obesity

For researchers designing insulin resistance or beta-cell function models, tirzepatides dual-receptor mechanism offers a distinct pharmacological profile that semaglutide cannot replicate
