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[4] CLINICAL TRIAL DATA Weight Loss Results Clinical trials show Zepbound produces significantly greater weight loss than Ozempic: Zepbound: SURMOUNT Trials Ozempic: SUSTAIN & STEP Trials Head-to-Head Data: SURMOUNT-5 (2025) The first direct head-to-head trial (SURMOUNT-5, published in NEJM May 2025) compared maximum doses over 72 weeks in 751 participants: tirzepatide achieved 20.2% weight loss (50.3 lbs/22.8 kg) vs

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If fatigue is limiting your ability to function normally, your provider may want to check labs or slow your dose increases

However, the medication's effect on your specific metabolic rate depends partly on whether your thyroid condition is well-controlled with medication like levothyroxine

The Three-Receptor Activation Pathway Retatrutide activates the glucagon-like peptide-1 receptor (GLP-1R), which signals satiety and improves insulin secretion in response to glucose

Weight loss typically ranges from 4-8 lb during the first month, with individual variation based on starting weight and caloric reduction achieved