new glp-1 drug retatrutide Promises Big Weight Loss, but Safety Remains a Question Retatrutide for weight loss: Study

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Notably, it is well established that glucagon-like peptide-1 (GLP-1), an incretin hormone of the glucagon superfamily, contributes to glucose-dependent pancreatic -cell insulin secretion

Incretin action in islets and implications for diabetes The findings that the acute insulinotropic actions of GLP-1, but not GIP, were relatively preserved in people with type 2 diabetes (T2D) (2) focused greater attention on the therapeutic potential of GLP-1, ultimately supporting multiple clinical development programs for GLP-1 receptor (GLP-1R) agonists (GLP-1RA)

Maladaptive O-GlcNAc protein modification serves as a critical regulator of the diabetic phenotype in human hearts