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48 The mechanism by which GLP-1 RA regulates mitochondrial function and oxidative stress has not been well elucidated

While there has been no clear association with certain psychiatric side effects, such as depression or suicidal ideation in research-based 31 or real-world 32 samples, the potential modulation of reward pathways by these drugs necessitates vigilant monitoring in patients with psychiatric histories, particularly in the setting of treatment with a medication that can substantially modulate the response of appetitive neurocircuitry to natural rewards such as food and water

RT exposure during transport acceptable

In summary, our secretion assay is a robust tool for identifying and pharmacologically profiling novel GLP-1 stimulators , highlighting its potential for developing innovative therapeutic strategies for the treatment of diabetes and obesity