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A inibio do glucagon pela semaglutida contribui para a reduo da glicose sangunea em pacientes com DM2

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Sources: FDA data Once-Weekly Semaglutide in Adults with Overweight or Obesity NEJM DOI: 10.1056/NEJMoa2032183 Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension Diabetes, Obesity and Metabolism DOI: 10.1111/dom.14725

The failure nodes include: Gut inflammation & dysbiosis Excess DPP-4mediated GLP-1 degradation Insulin resistance Impaired vagalbrain signaling Mitochondrial dysfunction in L-cells Ayurvedic translation (systems concordance) GLP-1 dysfunction maps precisely to: Agnimandya (low digestivemetabolic fire) Ama accumulation (metabolic toxins) KaphaMeda dushti (obesity, insulin resistance) PranaSamana Vata imbalance (gutbrain satiety failure) Advanced stage: Madhumeha Ayurveda predicted GLP-1 logic thousands of years ago through the AgniAmaKapha axis
doi: 10.1152/ajprenal.00729.2010 92 BareticMKusecVPavlic-RenarI