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These drugs also influence macrophage activation, thereby shifting the immune response from a pro-inflammatory (M1) state towards an anti-inflammatory (M2) state

Ongoing studies, such as the SOUL trial, are exploring the potential cardiovascular benefits of oral semaglutide in T2DM patients with established atherosclerotic cardiovascular disease and/or chronic kidney disease [50]

The resulting increase in vagal toe inhibits gastric emptying and gastric acid secretion, subsequently resulting in a delay of gastric emptying, and reduction of glucose absorption (Shaefer et al, 2015)

Their clinical utility, however, differs by formulation and pharmacokinetic profile

The favorable reimbursement policies also govern the market growth

Our exclusion criteria comprised non-original designs, studies investigated on internal GLP-1, studies lacking weight change outcomes, studies without all population undergoing bariatric surgery, absence of baseline patient characteristics