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A meta-analysis of cardiovascular outcome in patients with long disease duration including Action to Control Cardiovascular Risk in Diabetes (ACCORD), Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE), and Veterans Affairs Diabetes Trial (VADT) suggested that in these populations the reduction of ~1% in A1C is associated with a 15% relative reduction in nonfatal myocardial infarction (4)

We encourage you to discuss with your healthcare provider whether GLP-1 therapy is the right option for you.

IGF-1 mediates many of GHs anabolic effects, including protein synthesis and cellular repair

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The first oral (pill) form of a GLP-1 (semaglutide, brand name Wegovy) became available in January 2026

Moreover, decreased proglucagon gene expression (which is crucial in GLP-1 encoding) leads to heightened appetite and consequential weight gain [26]