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Description
No difference was observed between frailty groups

Specifically, retatrutide is intended to activate the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor a combination that distinguishes it from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 receptor agonist)

In 2025, oral semaglutide adoption increased by 22%, driven by improved formulations

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Secondary endpoints: Change in ADCS-ADL-MCI (up to week 104) and time to worsening in CDR (up to week 156)

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