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Another study a meta-analysis and review of 78 trials involving more than 73,000 participants concluded that semaglutide was associated with an increased incidence of NAION but emphasized that evidence for a causal link remains inconclusive

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In addition to profoundly compromising quality of life and daily functioning, this disorder contributes to the pathogenesis of numerous chronic diseasesincluding hypertension, coronary artery disease, stroke, diabetes, and cognitive impairmentand has been correlated with elevated all-cause mortality risk (46)

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