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2001;280:R536R546
SGLT2is exhibits multiple beneficial effects beyond glycemic control, including reductions in body weight, blood pressure, and cardiovascular events 5

This approach aligns with broader trends toward de-risking early-stage development by leveraging validated biology and emphasizes the importance of translational rigor over novelty alone

Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu 215500, Jiangsu Province, China

doi: 10.1073/pnas.1817391116 69 PerryTHaugheyNJMattsonMPEganJMGreigNH
