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For retatrutide, this takes 4 to 5 weeks of weekly dosing at a given dose level

It remains strictly in the investigational phase and cannot be legally prescribed or sold at retail in its current form

Patients were excluded if they had any other chronic liver disease other than MASLD/MASH including alcohol, viral, drug-induced, autoimmune, Budd-Chiari syndrome, Wilsons disease, alpha-1-antitrypsin deficiency, hereditary hemochromatosis, primary/secondary biliary cholangitis, primary sclerosing cholangitis, liver disorders in diseases classified elsewhere, and other chronic hepatitis not classified elsewhere

The magnitude of metabolic adaptation typically correlates with the speed and extent of weight loss

Keep water within reach and sip through the day

When considering injectable-based combination therapy, GLP-1RAs are preferred over basal insulin (RCT, General) [47]