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Findings In this randomized clinical trial including 60 US adults with a prespecified interim analysis, the rate of clinically significant RGV was 25.0% vs 3.1% when GLP-1/GIP agonists were continued vs held, respectively, in the periprocedural period

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I would not be surprised if SUD eventually became a clinical indication for using a GLP-1. Lacking that, DeRoo said that the ideal patients who can benefit from GLP-1 off-label uses across mental health are those who already meet clinical criteria to receive a prescription for a GLP-1

The decision to prescribe these medications should involve careful consideration of individual patient factors, thorough informed consent processes, and commitment to ongoing monitoring and support

They became broadly available as a result of the drug shortage declared in 2022, but that legal foundation has since eroded

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