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Never extend your dosing interval to every two weeks without explicit medical advicethis constitutes off-label use without supporting evidence and may compromise both safety and effectiveness

Half of the group was given tirzepatide over the course of 52 weeks, the other half was given a placebo

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ALT has been demonstrated to decline in patients with treatmentrelated improvement or resolution of histological NASH in studies of obeticholic acid,45 elafibranor46 and liraglutide,23 and also shown to decline in association with liver fat reductions among patients with type 2 diabetes and NAFLD treated with the sodiumglucose cotransporter 2inhibitor empagliflozin.47 While correlated outcomes do not always indicate a causative association, several studies have also observed a predictive association between changes in ALT and subsequent NAFLD/NASHrelated outcomes