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GLP-1 receptors are distributed throughout the brain, with concentrations in the hypothalamus, brainstem, and areas involved in reward processing

it is a set of conditions with different drivers, so one breakthrough rarely helps everyone, Shamsa Kanwal, a board-certified dermatologist with over 10 years of clinical experience, told DDN

- **Naltrexone/Bupropion (Contrave)**: Influences hypothalamic appetite centers and the reward system to reduce cravings, with side effects like nausea, headache, and contraindication in seizure disorders

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Don't use it if they've got family history of medullary thyroid cancer or MEN 2

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