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The other phase IIa study also confirmed improved glycemic control in those with obesity and T2DM, but also reported decreased body weight and improvement of blood lipids compared to placebo [44]

After completing its evaluation of one application in May 2025, the European Food Safety Authority stated that the safety of allulose requires additional data , but the applicant had not replied

Plasma glucose also tended to decrease during the first 48 h (162126 mg/dl), accompanied by a parallel decrease in plasma insulin levels (184118 pmol/L) consistent with the insulinomimetic effects of GLP-1

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