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[DOI] [PubMed] [Google Scholar] 10.Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial

As a dual GIP/GLP-1 receptor agonist, it targets two hormone pathways simultaneously a mechanism that explains why clinical trials have shown it outperforming older single-agonist medications in head-to-head comparisons

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Allometric principles were incorporated into the tirzepatide PK base model with body weightbased allometric exponents included as fixed values on CL and volume of distribution ( V d ) parameters