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Common side effects include nausea, bloating, or digestive changes, especially during the semaglutide side effects first week, which usually improve over time

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During this initial period, it's wise to avoid particularly greasy or high-fat foods while your digestive system adapts to its new normal

Because GLP-1 improves body weight and glucose metabolism in humans (42, 43), designing single peptides co-agonists at GLP-1R and GCGR may produce superior body weight benefits to GLP-1R agonism alone and could mitigate the effect of glucagon on glucose production