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[13] [14] Some historical or research protocols have used much higher doses (e.g., 250 mg/kg as a single IV bolus in diagnostic growth-hormone testing), but such regimens are uncommon outside controlled studies

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In addition, the inhibitory effect of intragastric nutrient infusion on food-motivated behaviors may operate via sex-specific pathways as ip injection of the GLP-1R antagonist exendin-9 prevents the reduction in operant responding following nutrient infusion in male but not female rats [92]