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All GLP-1 agonists require a prescription, which can be obtained through a licensed practitioner depending on eligibility criteria

In advanced PDR, escalating retinal ischemia and hypoxia enable diffusible mediators - such as Ang-2, TNF-, VEGF, and the semi-diffusible VEGF isoform - to migrate anteriorly down the vitreal gradient into the anterior chamber, where they drive neovascularization of the iris and angle, a hallmark of neovascular glaucoma (NVG)

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While it is not yet known if this risk translates to humans, the warning exists as a precaution

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doi: 10.1016/S2213-8587(21)00174-1