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The majority of people who experience initial symptoms find them manageable or see them resolve over time

Nat Rev Endocrinol 8, 728742 (2012)

showed in rats that GLP-1(736) increases myocardial energy efficiency by substrate shifting to glucose (60)

Ultimately, whether you taper off semaglutide or stop at your current dose is a decision best made with your provider, based on how long youve been on the medication, your current dose, and your goals going forward

Fatigue appears in 8-12% of users, though distinguishing medication-induced fatigue from diet-related energy deficits proves difficult

Clinical trials have demonstrated that nausea, vomiting, diarrhoea, and abdominal discomfort are amongst the most commonly reported adverse reactions, particularly during the initial weeks of treatment or following dose escalation