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The SURPASS-CVOT trial is ongoing, and researchers should note that hard cardiovascular endpoint data for tirzepatide remain less mature than semaglutides [2]

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GLP1s effects on endothelial and adipose tissue leading to cardiovascular and neuroprotective effects are areas of particular interest

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A low risk of bias and no publication bias were found in these studies

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Additionally, the researchers highlighted that the use of DPP-4 inhibitors was also not associated with an increased risk of thyroid cancer (wHR 0.95, 95% CI 0.791.14) compared to that of SGLT2 inhibitors

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