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[DOI] [PubMed] [Google Scholar] 71.Holst JJ

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Il capostipite di questa nuova categoria di farmaci, gli analoghi recettoriali del GLP-1 (Glucagon Like Peptide-1), fu infatti scoperto nel 1992 nella saliva di questa grossa lucertola dellArizona in grado, durante i lunghi periodi di digiuno nel deserto, di abbassare il fabbisogno energetico e mantenere costante il livello di glucosio nel sangue

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Conclusion GLP-1 receptor agonists, originally developed for metabolic disorders, have emerged as promising therapeutics for a range of neurological diseases

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Centers for Disease Control and Prevention: Physical Activity and Your Weight and Health Mozaffarian D et al

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14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below

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