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It is not known if sitagliptin is dialyzable by peritoneal dialysis
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Extensive clinical experience has been reported using these medications in a wide spectrum of patients with T2DM and concomitant cardiovascular disease, chronic kidney disease, or obesity, among others

doi: 10.1186/s12933-021-01366-8

Because calorie intake ultimately drives changes in body composition, even modest appetite modulation could influence weight trends

It is possible that the medication interacts with these receptors in a way that lowers the pain threshold of the sensory nerves in the skin

a The study by Piotrowski et al
