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In pre-clinical studies, DA-1241 demonstrated a positive effect on liver inflammation, lipid metabolism, weight loss, and glucose metabolism, reducing hepatic steatosis, hepatic inflammation, and liver fibrosis, while also improving glucose control
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however most of these, such as the subgroups based on renal function in SUSTAIN-5 or subgroups based on A1C level at baseline in SUSTAIN-6, were not included as a stratification variable at randomization

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