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Depending on the presenting features, there are three different clinical manifestations of PCOS

Increased DAG levels inhibit PKC, leading to defective activation of IRS-1/PI3K/AKT insulin signaling, downregulation of GLUT4 and forthcoming insulin resistance [170,172]

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But its not a hopeless situation

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Clinical studies show modest weight loss of 2-5 pounds over 12 weeks, with more significant improvements in metabolic markers like fasting glucose and HbA1c