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The researchers also discovered that GLP-1 activated a signalling pathway in skin cells called MAPK/ERK, which is known to be involved in cell growth and division

In men with persistently low serum testosterone concentrations, reduced androgen-mediated anabolic support may theoretically increase vulnerability to skeletal muscle loss during weight reduction

Patients with multiple comorbidities, especially those with limited treatment options, are significantly more likely to initiate GLP1 therapy

Last reviewed: July 1, 2026 Last updated: July 1, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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Combining GLP-1s with metformin does not appear to worsen GI side effects, despite metformins association with similar symptoms