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Average body weight reduction: 5 mg weekly: 16.0% reduction (approximately 35 pounds for a 220-pound person) 10 mg weekly: 21.4% reduction (approximately 47 pounds) 15 mg weekly: 22.5% reduction (approximately 50 pounds) Placebo: 2.4% reduction Percentage of participants achieving clinically significant weight loss: 5% or more weight loss: 85% at 5 mg, 89% at 10 mg, 91% at 15 mg 10% or more weight loss: 69% at 5 mg, 78% at 10 mg, 84% at 15 mg 20% or more weight loss: 32% at 5 mg, 49% at 10 mg, 57% at 15 mg Look at those numbers carefully

Hydration becomes critically important when diarrhea is present

In animal studies, these drugs have demonstrated the ability to improve cognitive function, reduce brain inflammation, and even restore damaged neurons

"Polycystic Ovarian Syndrome." StatPearls , updated 7 July 2025, StatPearls Publishing, 2025 Jan

At 1 mg, roughly 25% to 30% experience nausea

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