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Abrupt cessation creates a hormonal whiplash that makes weight regain almost inevitable

171 IR is still the key link between diabetes and PD and may impair nigrostriatal dopamine function, 172 exacerbate nigrostriatal DA depletion, 173 and enhance cognitive impairment 174 and behavioral abnormalities
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The pharmaceutical versions mimic this hormone, plus a few others (GIP and glucagon)

10.1371/journal.pone.0077284 15 EgeciogluE.EngelJ
