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These include: Nausea (affecting up to 20% of patients) Vomiting Diarrhoea Constipation Abdominal pain or discomfort These symptoms are typically mild to moderate in severity and often improve over time as the body adjusts to the medication

Clinical trials show that when people lose weight on GLP1 drugs such as semaglutide and tirzepatide, they lose both fat and lean mass

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Li Z et al

8 grams protein, 140 calories

Preclinical models have suggested that stimulation of sGC in diabetes can increase cGMP formation, with resultant improvements in kidney inflammation/fibrosis, glomerular permeability and kidney blood flow [78]