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Finally, Anti-LOX, HCG, and VED did not increase or decrease ICP and ICP/MAP ratio, neither alone nor in combination

For instance, an incidence of acute pancreatitis was observed at 0.3% in the placebo group, highlighting potential risks associated with these medications

The challenge here is that reducing the risk of future adverse outcomes cannot be measured in the present of any particular patient

Notably, 92.8% of the weight lost was attributed to fat mass , far exceeding the 71.8% observed with semaglutide monotherapy

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Therefore, it is speculated that GLP-1 can indirectly affect bone metabolism by regulating the level of blood glucose (Terzi et al., 2015)