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These patients are at a greater risk of major cardiovascular events such as stroke, heart attack, or death

Both Nirchi and Long point to things like nausea and constipation, particularly when starting the drugs or titrating up to a higher dose (but for them, the benefits have outweighed the downsides)

Tirzepatide targets two hormone receptors instead of one and can produce higher average weight loss

GLP-1 (glucagon-like peptide 1) is a receptor agonist, a class of drugs originally designed to treat type 2 diabetes, with brand names such as Ozempic, Wegovy, and Mounjaro

West, S., Scragg, J., Aveyard, P., Oke, J

Medication Tolerance and Appetite Adaptation Over Time Tolerance to semaglutide can develop after 2-3 months of continuous use at the same dose, as your body adapts to the medication's effects on appetite signaling