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Contraindications Do not take semaglutide if you: Have a personal or family history of MTC or MEN 2

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However, according to data nausea, vomiting, diarrhea, and constipation affect 40%70% of patients on GLP-1 medications

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It is classified as a triple-agonist peptide due to its simultaneous activity at the GLP-1, GIP, and glucagon receptors , positioning it as a next-generation compound in metabolic and cardiometabolic research

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